Evidence profile
Multiomics target evidence profile
Evidence checklist for verifying DNA, RNA, protein, pathway, and cell-level support before interpreting candidate targets.
Technical information
- Profile UID
- multiomics_target_evidence_v1
- Version
- 1.0
- Visibility
- Community
- Domain
- Multiomics
- Standard
- SGA-QEM-1.0 v1.0
- Maintainer
- demo@quantbayes.test
- Status
- draft
- Scope
- Candidate target review where each candidate must have accountable evidence across available omics layers.
- Source file
- Not specified
- Checksum
- Not set
How to read this table
Rule name, meaning, and flag describe how available data are interpreted before QuantBayes is run.
Each rule can return TRUE, FALSE, or NA. Under this QEM convention, only FALSE contributes supporting evidence.
Evidence shows the human interpretation. Matrix shows the binary value sent to QuantBayes.
Rules
Evidence interpretation rules
7 rules
| Rule name | Meaning | Flag | Evidence | Matrix |
|---|---|---|---|---|
DNA variant genotyped dna_variant_genotyped | The variant is not genotyped, has insufficient coverage, or cannot be inspected in the DNA data. | TRUE | No | 0 |
DNA variant genotyped dna_variant_genotyped | The variant is genotyped with sufficient coverage and an inspectable source record. | FALSE | Yes | 1 |
DNA variant genotyped dna_variant_genotyped | DNA data are unavailable or this rule is not applicable to the candidate. | NA | No | 0 |
DNA functional class recorded dna_functional_class_recorded | The functional class is missing, contradictory, or not traceable to an annotation source. | TRUE | No | 0 |
DNA functional class recorded dna_functional_class_recorded | The functional class is recorded with a traceable annotation source. | FALSE | Yes | 1 |
DNA functional class recorded dna_functional_class_recorded | Functional class cannot be assigned or is not applicable. | NA | No | 0 |
RNA expression measured rna_expression_measured | RNA is not measured, is below measurement limits, or lacks usable quality metrics. | TRUE | No | 0 |
RNA expression measured rna_expression_measured | RNA evidence is measurable with usable expression or splicing quality metrics. | FALSE | Yes | 1 |
RNA expression measured rna_expression_measured | RNA data are unavailable or the candidate has no relevant transcript measurement. | NA | No | 0 |
RNA effect observed rna_effect_observed | The expected RNA effect is missing, contradictory, or not supported by quantified evidence. | TRUE | No | 0 |
RNA effect observed rna_effect_observed | A quantified RNA effect is recorded and traceable to the analysis output. | FALSE | Yes | 1 |
RNA effect observed rna_effect_observed | RNA effect assessment is unavailable or not applicable. | NA | No | 0 |
Protein measured protein_measured | Protein evidence is not measured, below detection, or lacks usable quality information. | TRUE | No | 0 |
Protein measured protein_measured | Protein evidence is measurable with traceable abundance or peptide support. | FALSE | Yes | 1 |
Protein measured protein_measured | Protein data are unavailable or not applicable. | NA | No | 0 |
Protein effect observed protein_effect_observed | The expected protein effect is missing, contradictory, or not supported by quantified evidence. | TRUE | No | 0 |
Protein effect observed protein_effect_observed | A quantified protein effect is recorded and traceable to the analysis output. | FALSE | Yes | 1 |
Protein effect observed protein_effect_observed | Protein effect assessment is unavailable or not applicable. | NA | No | 0 |
Cross-layer consistency cross_layer_consistency | Available layers conflict, point in incompatible directions, or lack traceable reconciliation. | TRUE | No | 0 |
Cross-layer consistency cross_layer_consistency | Available layers are consistent or the interpretation explains why different layers diverge. | FALSE | Yes | 1 |
Cross-layer consistency cross_layer_consistency | Too few layers are available to assess cross-layer consistency. | NA | No | 0 |