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Evidence profile

Biotech multiomics compound screen demo

Community example profile for ranking compound hits using orthogonal transcriptomic, proteomic, assay, and replication evidence.

Technical information

Profile UID
biotech_multiomics_qem_demo
Version
1.0
Visibility
Community
Domain
Other
Standard
SGA-QEM-1.0 v1.0
Maintainer
QuantBayes Studio examples
Status
example
Scope
Multiomics compound screening
Source file
Not specified
Checksum
Not set

How to read this table

Rule name, meaning, and flag describe how available data are interpreted before QuantBayes is run.

Each rule can return TRUE, FALSE, or NA. Under this QEM convention, only FALSE contributes supporting evidence.

Evidence shows the human interpretation. Matrix shows the binary value sent to QuantBayes.

Rules

Evidence interpretation rules

4 rules
Rule nameMeaningFlagEvidenceMatrix
Primary assay not replicated
primary_assay_not_replicated
The primary assay effect was not replicated.TRUENo0
Primary assay not replicated
primary_assay_not_replicated
The primary assay effect was replicated.FALSEYes1
Primary assay not replicated
primary_assay_not_replicated
Primary assay replication evidence is unavailable.NANo0
Transcriptomic signature absent
transcriptomic_signature_absent
The expected transcriptomic signature is absent.TRUENo0
Transcriptomic signature absent
transcriptomic_signature_absent
The expected transcriptomic signature is present.FALSEYes1
Transcriptomic signature absent
transcriptomic_signature_absent
Transcriptomic evidence is unavailable.NANo0
Proteomic support absent
proteomic_support_absent
Proteomic support is absent.TRUENo0
Proteomic support absent
proteomic_support_absent
Proteomic support is present.FALSEYes1
Proteomic support absent
proteomic_support_absent
Proteomic evidence is unavailable.NANo0
Toxicity contradiction
toxicity_contradiction
Toxicity contradicts the screening hypothesis.TRUENo0
Toxicity contradiction
toxicity_contradiction
No toxicity contradiction was observed.FALSEYes1
Toxicity contradiction
toxicity_contradiction
Toxicity evidence is unavailable.NANo0